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The duodenal switch (DS) is a type of weight-loss surgery that is primarily designed for individuals suffering from severe obesity and related health complications. This procedure combines two surgical techniques: a gastric reduction, which significantly decreases the size of the stomach, and a biliopancreatic diversion, which alters the way the intestines absorb nutrients. During the surgery, the surgeon removes a large portion of the stomach, creating a small, sleeve-like pouch that holds only a fraction of the food that the original stomach could accommodate. This drastic reduction in stomach size not only limits food intake but also promotes a feeling of fullness after consuming even small portions of food. Following this, the intestinal tract is rerouted so that a large portion of the small intestine is bypassed, which reduces the area available for nutrient absorption. As a result, patients are likely to experience malabsorption, meaning their bodies will absorb fewer calories and nutrients from what they eat. The duodenal switch procedure is particularly effective for individuals with a Body Mass Index (BMI) over 50 or for those who have not achieved significant weight loss through other means, such as diet and exercise. In addition to promoting weight loss, the surgery has demonstrated positive impacts on obesity-related conditions, including type 2 diabetes, hypertension, and high cholesterol, helping many patients achieve a healthier metabolic state. However, it is essential to consider that the duodenal switch requires a lifelong commitment to follow-up care and dietary modifications to ensure proper nutrition and prevent complications. Patients are encouraged to adopt a high-protein, low-carb diet, and may need to take vitamin and mineral supplements to mitigate risks of deficiencies due to the malabsorptive nature of the procedure. Although the duodenal switch has shown superior outcomes in terms of sustained weight loss and improvement in comorbidities compared to other bariatric surgeries, it is regarded as a more complex procedure with potential risks such as leakage, infection, or complications from the rerouting of the intestines. Therefore, a thorough evaluation by a qualified bariatric surgeon and a comprehensive understanding of the potential risks and benefits is essential before opting for this surgery. Overall, the duodenal switch stands out as a transformative option for patients looking to achieve significant weight loss and reclaim their health, with the caveat of needing careful management and adherence to post-operative guidelines for long-term success.